双特异性抗体研发进展

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双特异性抗体研发进展

来源：药物分析杂志 2019, Vol. 39 Issue (1): 78-85. DOI: 10.16155/j.0254-1793.2019.01.10

张峰 , 王开芹 , 王兰

摘要：双特异性抗体（bsAb）因可同时特异性结合2个不同抗原表位，拓展了治疗性单克隆抗体的临床应用范围。制备bsAb需要对传统的抗体结构进行改造，在此过程中衍生出了数十种结构，不同的结构具有不同的作用特点。本综述就当前典型的bsAb结构及其原理进行介绍，对bsAb的作用原理进行分析，并对当前代表性的bsAb的研发阶段进行了简单总结。

关键词：双特异性抗体（bsAb）单克隆抗体抗体结构研发进展

Development in bispecific antibody

ZHANG Feng, WANG Kai-qin, WANG Lan

Abstract: The clinical application of therapeutic monoclonal antibody has been extended by bispesific antibody (bsAb)due to their capacity of binding two different antigenic epitopes.Structure changing would be needed for the construction of bsAb.There are several tens of bsAb structures developed, the specific action characteristics of which are related with their unique bsAb structure.In this review, typical structures and acting principles of bsAb were introduced, the action principle of bsAb was analyzed, and the development stages of representative bsAb were briefly summarized.

Key words: bispecific antibody(bsAb) monoclonal antibody antibody structure research development

双特异性抗体研发进展

药物分析杂志 2019, Vol. 39 Issue (1): 78-85. DOI: 10.16155/j.0254-1793.2019.01.10

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